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- Title
Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines.
- Authors
Komoto, Tatiana Takahasi; Bernardes, Tayná Minervina; Mesquita, Thaís Balthazar; Bortolotto, Luis Felipe Buso; Bitencourt, Tamires Aparecida; Marins, Mozart; Fachin, Ana Lúcia; Silva, Gabriel; Baek, Seung Joon
- Abstract
In the present investigation, <italic>trans</italic>-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the <italic>trans</italic>-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins.
- Subjects
CHALCONES; GENETICS of breast cancer; CELL migration; CELL lines; MULTIDRUG resistance; AURORA kinases; METASTASIS; PREVENTION; GENETICS
- Publication
Molecules, 2018, Vol 23, Issue 8, p2018
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23082018