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- Title
Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity.
- Authors
Zhang, Tao; Si, Jin-Guang; Zhang, Qiu-Bo; Chen, Jia-Huan; Ding, Gang; Zhang, Hong-Wu; Jia, Hong-Mei; Zou, Zhong-Mei
- Abstract
Three new highly oxygenated (<bold>2</bold>–<bold>4</bold>), and two known (<bold>1</bold> and <bold>5</bold>) germacranolides, were isolated from the whole plant of <italic>Carpesium divaricatum</italic>. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of <bold>1</bold> was established using the circular dichroism (CD) method and X-ray diffraction, and the stereochemistry of the new compounds <bold>2</bold>–<bold>4</bold> were determined using similar CD spectra with <bold>1</bold>. The new compound <bold>2</bold> and the known compound <bold>5</bold> exhibited potent cytotoxicity against hepatocellular cancer (Hep G2) and human cervical cancer (HeLa) cells, superior to those of the positive control <italic>cis</italic>-platin.
- Subjects
BIOACTIVE compounds; ANTINEOPLASTIC agents; HERBAL medicine; MEDICINAL plants; CELL-mediated cytotoxicity
- Publication
Molecules, 2018, Vol 23, Issue 5, p1078
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23051078