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- Title
Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice.
- Authors
Dong Wook Lim; Hyun Jung Son; Min Young Um; In-Ho Kim; Daeseok Han; Suengmok Cho; Chang-Ho Lee
- Abstract
In the present study, we examined the ameliorating effects of demethoxycurcumin (DMC) on memory impairment induced by scopolamine using passive avoidance and Morris water maze tests in mice. Moreover, to determine the neurobiological effects underlying the ameliorating effects of the DMC, choline acetyltransferase (ChAT) immunoreactivity was evaluated in mice exposed to scopolamine. Our results demonstrated that chronic oral administration (28 days) of DMC (10 mg/kg) improved scopolamine-induced learning impairment in the passive avoidance task and memory impairment in the Morris water maze. Moreover, Choline acetyltransferase (ChAT) activity in the DMC-treated group was significantly increased to 33.03% compared with the control group. Our present finding suggests that DMC ameliorates memory impairments induced by scopolamine treatment through reversing the reduction of hippocampal ChAT expression in mice.
- Subjects
CURCUMIN; ANIMAL models of memory disorders; SCOPOLAMINE; ACETYLTRANSFERASES; LABORATORY mice
- Publication
Molecules, 2016, Vol 21, Issue 8, p1022
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21081022