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- Title
Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol.
- Authors
Motiwala, Hashim F.; Qin Yin; Aubé, Jeffrey
- Abstract
The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse functional groups and the corresponding nitriles were obtained in good to high yields without the need for aqueous work up.
- Subjects
AROMATIC aldehydes; NITRILES; PROPANOLS; HYDROGEN bonding; FUNCTIONAL groups
- Publication
Molecules, 2016, Vol 21, Issue 1, p45
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21010045