We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China.
- Authors
Bin Chen; Qiong Shen; Xun Zhu; Yongcheng Lin
- Abstract
Four new anthraquinone derivatives 1-4 were obtained along with seven known compounds 5-11 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compound 1 is a novel tetrahydroanthraquinone with an epoxy ether bond between C-4a and C-9a. In the primary bioassays, compound 3 (alterporriol T) exhibited inhibition of a-glucosidase with a IC50 value 7.2 μM, and compound 9 showed good inhibitory activity against the HCT-116 and HeLa cell lines, with IC50 values of 3.03 and 8.09 μM, respectively.
- Subjects
CHINA; ANTHRAQUINONE derivatives; ALTERNARIA; SALT lakes; CELL lines; NUCLEAR magnetic resonance spectroscopy
- Publication
Molecules, 2014, Vol 19, Issue 10, p16529
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules191016529