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- Title
miR-138 promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through the SIRT1/p-STAT3 pathway.
- Authors
Zhang, Shanchao; Liu, Lei; Wang, Ruijin; Tuo, Houzhen; Guo, Yanjun; Yi, Li; Wang, Dexin; Wang, Jiawei
- Abstract
Human cytomegalovirus (HCMV) has been reported to be linked to vascular disease through the induction of neovessel formation. We have previously reported that microRNA (miR)-217 and miR-199a-5p enhance endothelial angiogenesis via inhibition of sirtuin 1 (SIRT1) in HCMV-infected human umbilical vein endothelial cells (HUVECs). Here, we found that miR-138 also suppressed the expression of the SIRT1 protein and stimulated phosphorylation of signal transducer and activator of transcription 3 (p-STAT3). Moreover, the regulation of p-STAT3 expression mediated by SIRT1 was found to promote HCMV-induced angiogenesis. These findings revealed that miR-138 might promote angiogenesis of HCMV-infected HUVECs by activating the SIRT1-mediated p-STAT3 pathway, and this could provide novel insights into HCMV-induced angiogenesis.
- Subjects
MICRORNA; VIRAL genomes; CYTOMEGALOVIRUSES; ENDOTHELIAL cells; STAT proteins; NEOVASCULARIZATION; SIRTUINS
- Publication
Archives of Virology, 2017, Vol 162, Issue 9, p2695
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-017-3423-0