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- Title
A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis.
- Authors
Phan, Tung; Messacar, Kevin; Dominguez, Samuel; Costa, Antonio; Deng, Xutao; Delwart, Eric
- Abstract
We characterized the genome of a densovirus, tentatively called human CSF-associated densovirus 1 (HuCSFDV1), in cerebrospinal fluid (CSF) from a human case of encephalitis with antibodies against the N-methyl D-aspartate receptor. The presence of the viral genome in CSF was independently confirmed. This virus, which is proposed to be a member of a new species in the genus Iteradensovirus of the subfamily Densovirinae, showed the typical two ORFs encoding nonstructural and structural proteins with low-level identities of 22 and 16 % to the closest known densovirus relative. No other eukaryotic viral sequences were detected using deep sequencing. The replication and pathogenicity in humans of this virus, which belongs to a viral subfamily whose members are only known to replicate in invertebrates, remain to be demonstrated. Alternative explanations for the detection of densovirus DNA in CSF are discussed.
- Subjects
CEREBROSPINAL fluid examination; ANTI-NMDA receptor encephalitis; VIRAL genomes; ASPARTATE receptors; EUKARYOTIC genomes
- Publication
Archives of Virology, 2016, Vol 161, Issue 11, p3231
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-016-3002-9