We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A microRNA polycistron as a potential human oncogene.
- Authors
He, Lin; Thomson, J. Michael; Hemann, Michael T.; Hernando-Monge, Eva; Mu, David; Goodson, Summer; Powers, Scott; Cordon-Cardo, Carlos; Lowe, Scott W.; Hannon, Gregory J.; Hammond, Scott M.
- Abstract
To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17–92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17–92 locus are often substantially increased in these cancers. Enforced expression of the mir-17–92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17–92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17–92 cluster as a potential human oncogene.
- Subjects
ONCOGENES; RNA; LYMPHOPROLIFERATIVE disorders; STEM cells; NUCLEIC acids; HEMATOPOIETIC stem cells; BONE marrow cells; APOPTOSIS
- Publication
Nature, 2005, Vol 435, Issue 7043, p828
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature03552