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- Title
Mitochondrial permeability: Dual role for the ADP/ATP translocator?
- Authors
Kokoszka, J. E.
- Abstract
Arising from: J. E. Kokoszka et al. 427, 461-464 (2004)The ADP/ATP translocator (or adenine nucleotide translocase; ANT) is thought to play a dual role: in the transport of ADP and ATP across the mitochondrial inner membrane and in the formation of the mitochondrial permeability-transition pore (mtPTP), a nonspecific pore that is an important mediator of apoptosis (programmed cell death). However, Kokoszka et al. have shown that mitochondria from livers of ‘ANT-knockout’ mice, in which the ANT has been genetically inactivated, still possess mtPTP activity. From this, the authors conclude that the ANT is a non-essential component of the mtPTP that may be dispensable for mtPTP-associated cell death. These results, which contradict previous evidence and cast doubt on a widely accepted model for the mtPTP (ref. 1), warrant scrutiny and call for a fundamental reappraisal of the role of the ANT in liver metabolism.
- Subjects
MITOCHONDRIA; APOPTOSIS; ADENINE nucleotides; METABOLISM; LIVER; CELL death
- Publication
Nature, 2004, Vol 430, Issue 7003, p1
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature02816