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- Title
Choice of Tactics for Experimental Therapy of Chronic Heart Failure with ALM-802 Compound.
- Authors
Barchukov, V. V.; Tsorin, I. B.; Vititnova, M. B.; Efimova, A. O.; Likhosherstov, A. M.; Mokrov, G. V.; Kryzhanovskii, S. A.
- Abstract
The cardioprotective activity of ALM-802 compound was demonstrated in model experiments simulating postinfarction chronic heart failure in rats forming in 90 days after anterior transmural myocardial infarction. ALM-802 decreased the left ventricle and improved its inotropic function (p=0.038). This effect was observed in case of systematic administration of ALM-802 over 28 days (starting from day 91 after infarction modeling). This is apparently the minimum time for the cardioprotective effect of ALM-802 to prevent or treat the resulting heart failure, because short-term systematic therapy (15 days) produced no positive effect.
- Subjects
HEART failure; INVESTIGATIONAL therapies; MYOCARDIAL infarction; INFARCTION; MYOCARDIAL reperfusion
- Publication
Bulletin of Experimental Biology & Medicine, 2021, Vol 170, Issue 6, p774
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-021-05152-0