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- Title
AKT/mTOR Signal Cascade and Expression of PD-1, PD-L1, and PD-L2 in Gastric Cancer.
- Authors
Spirina, L. V.; Avgustinovich, A. V.; Afanas'ev, S. G.; Kondakova, I. V.; Volkov, M. Yu.; Dobrodeev, A. Yu.; Boronkina, A. I.
- Abstract
The peculiarities of gastric cancer development associated with the expression levels of components of the AKT/mTOR signaling cascade and PD, PD-L1, PD-L2 have not yet been identified. We revealed the fundamental changes in the expression AKT/mTOR and PD receptors and their ligands associated with dissemination of gastric cancer. An increase in the mRNA level of all components of this cascade was demonstrated. The expression of mTOR and AKT decreased against the background of enhanced expression of PTEN phosphatase. The increase in the expression of PD-1 receptors and PD-L1 and PD-L2 ligands was most pronounced in patients with distant metastases.
- Subjects
PROGRAMMED death-ligand 1; STOMACH cancer; PROGRAMMED cell death 1 receptors; CANCER invasiveness; METASTASIS; MESSENGER RNA
- Publication
Bulletin of Experimental Biology & Medicine, 2020, Vol 170, Issue 1, p75
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-020-05007-0