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- Title
Combined Effect of TLR2 Ligands on ROS Production by Mouse Peritoneal Macrophages.
- Authors
Teselkin, Yu. O.; Khoreva, M. V.; Veselova, A. V.; Babenkova, I. V.; Osipov, A. N.; Gankovskaya, L. V.; Vladimirov, Yu. A.
- Abstract
TLR2-mediated ROS production by mouse peritoneal macrophages was studied by luminoldependent chemiluminescence under conditions of cell stimulation with zymosan (TLR2/6 ligand) and peptidoglycan (TLR2/1 ligand). ROS production by macrophages stimulated with zymosan and peptidoglycan simultaneously depended on the ratio of ligand concentrations. Three effects were revealed: additivity of the stimulating effects of the ligands used, competitive ligand binding, and effect of macrophage priming with peptidoglycan during cell stimulation with zymosan. The mechanisms of these effects are discussed.
- Subjects
MACROPHAGES; CYTOKINES; LIGANDS (Biochemistry); PERITONEAL dialysis
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 166, Issue 1, p26
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4281-9