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- Title
Inhibition of Apoptosis Stages of Human Blood Lymphocytes after Exposure to Carbon Monoxide in the Presence of Recombinant Interleukin-2.
- Authors
Artyukhov, V.; Tyunina, O.
- Abstract
We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of recombinant IL-2 was accompanied by accumulation of Bcl-2 protein with simultaneous decrease of survivin content. It was concluded that carbon monoxide plays a role in the dysregulation of apoptosis of human blood lymphocytes Bcl-2 ( i.e. CO inhibits the proapoptotic effect of recombinant IL-2).
- Subjects
APOPTOSIS prevention; CARBON monoxide; INTERLEUKIN-2; LYMPHOCYTES; THERAPEUTIC use of cytokines
- Publication
Bulletin of Experimental Biology & Medicine, 2017, Vol 162, Issue 3, p362
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-017-3616-2