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- Title
Role of NF-κB-Dependent Signaling in the Realization of Growth Potential of Mesenchymal Progenitor Cells in Vitro.
- Authors
Zyuz'kov, G.; Danilets, M.; Ligacheva, A.; Zhdanov, V.; Udut, E.; Miroshnichenko, L.; Simanina, E.; Trofimova, E.; Minakova, M.; Chaikovskii, A.; Agafonov, V.; Dygai, A.
- Abstract
Signal pathways of realization of growth potential of mesenchymal progenitor cells related to transcription factor NF-κB were studied in vitro. NF-κB was found to participate in the proliferation and differentiation of progenitor elements that can be blocked by its specific inhibitor oridonin. NF-κB inhibitor aurothiomalate had no effect on the functions of fibroblastic CFU.
- Subjects
NF-kappa B; CELLULAR signal transduction; MESENCHYMAL stem cells; PROGENITOR cells; CELL proliferation; IN vitro studies
- Publication
Bulletin of Experimental Biology & Medicine, 2013, Vol 155, Issue 6, p721
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-013-2236-8