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- Title
(E)-3-(Aryl(arylamino)methylene)indolin-2-one derivatives: an efficient synthetic approach and evaluation of their cancer inhibitory activity.
- Authors
Hongwu Jiang; Zhiyuan Feng; Taiping Chena; Zicheng Li; Wencai Huang; Youfu Luo; Yinglan Zhao
- Abstract
A series of ( E)-3-(aryl(arylamino)methylene)indolin-2-one derivatives were synthesised using an efficient synthetic approach. The method involved reaction of 3-bromo-3-(bromo(aryl)methyl)indolin-2-one with substituted anilines through nucleophilic substitution and a simultaneous elimination using NaHCO3 in DMF. The anticancer activity of the products against four cell lines, HCT-116, A549, SKOV3 and MDA-MB-231, was also evaluated, and several compounds showed moderate inhibitory activity.
- Subjects
INDOLE derivatives; ANTINEOPLASTIC agent synthesis; INDOLINONE; NUCLEOPHILIC substitution reactions; ELIMINATION reactions; DIMETHYLFORMAMIDE; SODIUM bicarbonate; STRUCTURE-activity relationship in pharmacology
- Publication
Journal of Chemical Research, 2018, Vol 42, Issue 1, p44
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/174751918X15166485941737