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- Title
A Study of the Impact of Serum Melatonin Level on Males Infertility and Reproductive Hormones and its Correlation to Semen Parameters.
- Authors
Alsaleh, Fahad K.; Alzamily, Ajil A.
- Abstract
Background: Infertility is the inability of couples to achieve pregnancy after one year of regular unprotected coitus. Infertility is the problem of 15% of young couples in different countries and male factor infertility accounts for 50% of cases. Melatonin or 5-methoxy-N-acetyltryptamine was discovered by Aaron Lerner in 1958 while studying bovine pineal glands. Significant advancements have been made in the research on melatonin, which has revealed its vital roles in regulating sleep-wake cycle rhythms, decelerating the aging process, and functioning as an antioxidant or anti-inflammatory agent. Additionally, melatonin, a critical component in reproductive functions, can eliminate free radicals such as (ROS). Objective: The present study aims to evaluate the impact of Melatonin on male infertility. Materials and methods: Serum melatonin was measured by using the Elabscience ELISA kit. A case-control study included the fertile group as the control (n=40) and the infertile group (n=50). All the subjects were included in this study between October 2022 and June 2023. The diagnosis of the participants was executed by a medical senior based on clinical characteristics, the history of patients, and biochemical tests. Age, family history, and BMI were measured. Blood samples were provided by each participant for the biochemical estimation of serum melatonin, FSH, LH, and testosterone. While semen samples were collected from each participant for the seminal fluid analysis. Results: The results of this study showed a decrease in the level of melatonin in infertile men as compared with fertile men. Moreover, there was no significant correlation between melatonin and FSH, LH, testosterone, and some semen parameters. Conclusions: The study indicated that decreased melatonin levels can be associated with male infertility, but it did not indicate a direct relationship between melatonin and hormone levels or specific semen parameters.
- Subjects
MALE infertility; SEMEN; MELATONIN; PINEAL gland; SLEEP-wake cycle; FREE radicals
- Publication
Al-Qadisiah Medical Journal, 2023, Vol 19, Issue 1, p4
- ISSN
1817-0153
- Publication type
Article
- DOI
10.28922/qmj.2023.19.1.4-8