We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinical efficacy of alternative TNF inhibitor and secukinumab between primary non-responder and secondary non-responde.
- Authors
Hong Ki Min; Hae-Rim Kim; Sang-Heon Lee; Yeon Sik Hong; Moon-Young Kim; Sung-Hwan Park; Kwi Young Kang
- Abstract
Objectives: To compare the drug retention times and clinical efficacy of alternative tumour necrosis factor inhibitors (TNFi) and secukinumab in primary and secondary non-responders with ankylosing spondylitis (AS). Methods: AS patients treated with biologics and enrolled in the Korean College of Rheumatology Biologics registry were examined. Patients who did not respond to previous TNFi treatment were defined as primary and secondary non-responders. Data regarding drug discontinuation and clinical efficacy were collected after 1 year. Kaplan–Meier and Cox regression analyses were performed to compare drug survival and associated factors. Logistic regression analyses were conducted to compare the clinical efficacy secukinumab with that of alternative TNFi. Results: In total, 124 patients (83 receiving alternative TNFi and 41 receiving secukinumab) had biologic changes due to clinical inefficacy. Drug retention rates in the alternative TNFi and secukinumab groups were similar (P = 0.096). However, subgroup analyses including only secondary non-responders revealed that secukinumab users showed a higher hazard ratio (HR) for drug discontinuation (HR = 3.77, P = 0.045). In addition, secukinumab was negatively associated with achieving BASDAI50 or a major improvement in the ASDAS. Conclusion: Alternative TNFi showed better drug retention and clinical efficacy in AS patients experiencing previous TNFi failure, in secondary non-responders. Therefore, alternative TNFi may be a more suitable treatment for secondary non-responders.
- Subjects
LOGISTIC regression analysis; ANKYLOSING spondylitis; RF values (Chromatography)
- Publication
Modern Rheumatology, 2023, Vol 33, Issue 1, p194
- ISSN
1439-7595
- Publication type
Article
- DOI
10.1093/mr/roac005