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- Title
Association of KIR genotype with susceptibility to HLA-B27-positive ankylosing spondylitis.
- Authors
Wang, Sheng; Li, Guixing; Ge, Rui; Duan, Zhenhua; Zeng, Zhen; Zhang, Tianchen; Gao, Jing; Yang, Ting; Liu, Si; Wu, Shanshan; Fan, Dazhi; Xu, Shengqian; Xu, Jianhua; Zhang, Li; Shuai, Zongwen; Ye, Dongqing; Zou, Yanfeng; Pan, Faming
- Abstract
Objective: Recent studies have explored the role of killer cell immunoglobulin-like receptors (KIRs) in chronic autoimmune diseases. The purpose of this study was to demonstrate whether KIR genes contribute to the pathogenesis of ankylosing spondylitis (AS) in Chinese populations. Methods: Sixteen KIR genes were genotyped from 60 unrelated patients with AS and 60 HLA-B27-positive matched healthy controls by PCR-SSP. The frequencies of the KIR alleles and genotypes in the AS and control groups were assessed by the χ test. Results: Our results showed that the frequency of the activator receptor KIR3DS1 gene in the AS group was significantly increased compared to the controls ( χ = 5.263, P = 0.006, OR = 3.059, 95 % CI = 1.357-6.896). Moreover, the frequency of the KIR3DL1/3DS1 genotype was greater in the AS group than in the control group ( P = 0.039, OR = 3.059, 95 % CI = 1.357-6.896). In contrast, the frequency of the no KIR3DL1/no 3DS1 genotype was lower in patients with AS compared with the controls ( P = 0.032, OR = 0.110, 95 % CI = 0.013-0.911). Conclusion: KIR3DS1, in addition to HLA-B27, may play an important independent role in the pathogenesis of AS in the Chinese population.
- Subjects
KILLER cell receptors; DISEASE susceptibility; ANKYLOSING spondylitis; AUTOIMMUNE diseases; CHRONIC diseases; CHINESE people; CONTROL groups; GENETICS; DISEASES
- Publication
Modern Rheumatology, 2013, Vol 23, Issue 3, p538
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/s10165-012-0692-z