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- Title
Sodium MRI of T1 High Signal Intensity in the Dentate Nucleus due to Gadolinium Deposition in Multiple Sclerosis.
- Authors
Eisele, Philipp; Konstandin, Simon; Szabo, Kristina; Ong, Melissa; Zöllner, Frank; Schad, Lothar R.; Schoenberg, Stefan O.; Gass, Achim; Zöllner, Frank
- Abstract
<bold>Background and Purpose: </bold>Recently, several studies reported increased signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance imaging (MRI) as a possible consequence of multiple applications of gadolinium-based contrast agents. The aim of this study was to investigate with sodium (23 Na) MRI possible tissue abnormalities of the DN in multiple sclerosis (MS) patients.<bold>Methods: </bold>Sodium and conventional MRI were performed on a clinical 3T scanner. Total sodium concentrations (TSCs) of the DN, as well as DN-to-pons and DN-to-cerebellum SI ratios on unenhanced T1-weighted MRI were calculated.<bold>Results: </bold>A total of 18 subjects (6/18 normal controls, 12/18 MS patients [6/12 with T1 hyperintense DN]) were investigated. There was no significant difference of TSC values of the DN in MS patients with a T1-hyperintense DN (33.70 ± 2.14 mM) compared to MS patients without those signal abnormalities (33.29 ± 1.67 mM; P = .67) or to healthy controls (33.14 ± 1.12; P = .32).<bold>Conclusions: </bold>Normal sodium signal in the T1-hyperintense DN in MS patients may point to relative tissue integrity despite gadolinium deposition in this area.
- Subjects
MULTIPLE sclerosis; SODIUM; MAGNETIC resonance imaging; DENTATE nucleus; GADOLINIUM; PATIENTS
- Publication
Journal of Neuroimaging, 2017, Vol 27, Issue 4, p372
- ISSN
1051-2284
- Publication type
journal article
- DOI
10.1111/jon.12448