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- Title
Changes in blood pancreatic polypeptide and ghrelin concentrations in response to feeding in sheep.
- Authors
Takahashi, H.; Kurose, Y.; Suzuki, Y.; Yamaguchi, T.; Yoshida, Y.; Azuma, Y.; Sugino, T.; Kojima, M.; Kangawa, K.; Hasegawa, Y.; Kobayashi, S.
- Abstract
The roles of pancreatic polypeptide (PP) have not been determined in ruminant animals. The aim of the present study was to examine the role of PP in the regulation of ghrelin secretion in sheep. Two experiments were conducted using four 2–yr–old Suffolk wethers fed a maintenance diet of alfalfa hay cubes. In Exp. 1, the effects of feeding on blood ghrelin and PP concentrations were examined in scheduled–fed sheep. Blood samples were collected every 10 mm from 30 mm before to 360 mm after feeding. Plasma PP concentrations were transiently increased from the preprandial average value to the values from 30 to 60 mm after feeding and gradually decreased (P < 0.05) to stable values from 150 to 180 mm. The values from 30 to 60 mm were greater (P < 0.05) than those from 150 to 360 miii. In contrast, plasma ghrelin concentrations were gradually decreased (P < 0.01) by feeding. The values from 60 to 360 mm were less (P < 0.01) than the preprandial average value. In Exp. 2, the effects of continuous PP infusion on ghrelin secretion were examined in feed–deprived sheep. The animals were deprived of feed for 48 h before PP infusion. The PP–treated group intravenously received synthetic bovine PP at a rate of 10 pmolkg-1 of BW-1min-1 for 180 mm. Blood samples were collected every 10 mm from 30 mm before to 180 mm after the commencement of PP infusion. Plasma PP concentrations reached a plateau within 30 mm after the commencement of PP infusion. Plasma ghrelin concentrations were decreased (P = 0.002, 0.016, 0.007) by PP infusion at 160, 170, and 180 mm, respectively. In conclusion, plasma ghrelin and PP concentrations were decreased and increased, respectively, in response to feeding in ruminant animals. Furthermore, PP could depress ghrelin secretion.
- Subjects
POLYPEPTIDES; GHRELIN; SHEEP feeding; ALFALFA as feed; RUMINANT feeding &; feeds; PANCREATIC secretions; BLOOD plasma; SECRETION; INFUSION therapy
- Publication
Journal of Animal Science, 2010, Vol 88, Issue 6, p2103
- ISSN
0021-8812
- Publication type
Article
- DOI
10.2527/jas.2009-1920