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- Title
Identification of quantitative trait loci affecting corpora lutea and number of teats in a Meishan x Duroc F<sub>2</sub> resource population.
- Authors
Sato, S.; Atsuji, K.; Saito, N.; Okitsu, M.; Komatsuda, A.; Mitsuhashi, T.; Nirasawa, K.; Hayashi, T.; Sugimoto, Y.; Kobayashi, E.
- Abstract
Understanding of the genetic control of female reproductive performance in pigs would offer the opportunity to utilize natural variation and improve selective breeding programs through marker-assisted selection. The Chinese Meishan is one of the most prolific pig breeds known, farrowing 3 to 5 more viable piglets per litter than Western breeds. This difference in prolificacy is attributed to the Meishan's superior prenatal survival. Our study utilized a 3-generation resource population, in which the founder grandparental animals were purebred Meishan and Duroc pigs, in a genome scan for QTL. Grandparent, F1, and F2 animals were genotyped for 180 microsatellite markers. Reproductive traits, including number of corpora lutea (number of animals = 234), number of fetuses per animal (n = 226), number of teats (n = 801), and total number born (n = 288), were recorded for F2 females. Genome- wide significance level thresholds of 1, 5, and 10% were calculated using a permutation approach. We identified 9 QTL for 3 traits at a 10% genome-wise significance level. Parametric interval mapping analysis indicated evidence of a 1% genome-wise significant QTL for corpora lutea on SSC 3. Nonparametric interval mapping for number of teats found 4 significant QTL on chromosomes SSC3 (P < 0.01), SSC7 (P < 0.01), SSC8 (P < 0.01), and SSC12 (P < 0.05). Partial imprinting of a QTL affecting teat number (P < 0.10) was detected on SSC8. Using the likelihood-ratio test for a categorical trait, 2 QTL for pin nipples were detected on SSC2 and SSC16 (P < 0.01). Fine mapping of the QTL regions will be required for their application to introgression programs and gene cloning.
- Subjects
SWINE; MAMMAL reproduction; DUROC Jersey swine; SWINE breeds; ANIMAL breeding; MOLECULAR cloning; GENETICS; GENOMES; PHENOTYPES
- Publication
Journal of Animal Science, 2006, Vol 84, Issue 11, p2895
- ISSN
0021-8812
- Publication type
Article
- DOI
10.2527/jas.2006-176