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- Title
Intestinal Permeability to Glucose after Experimental Traumatic Brain Injury: Effect of Gadopentetate Dimeglumine Administration.
- Authors
Santos, Alejandro; Gonçalves, Pedro; Araújo, João R.; Martel, Fátima
- Abstract
Traumatic injuries are the leading cause of mortality in individuals aged 1–44 years, and brain injury significantly contributes to the outcome in nearly one half of all deaths from trauma. At the intestinal level, traumatic brain injury (TBI) induces profound effects, including gastrointestinal mucosa ischaemia and motility dysfunction. However, nothing is known concerning the effect of TBI on the intestinal absorption of glucose. Hence, the aim of this study was to investigate the effect of TBI on the intestinal absorption of glucose by investigating the effect of TBI on the jejunal mucosal-to-serosal apparent permeability (AP-to-BL Papp) to two glucose model substrates, 3H-2-deoxy-D-glucose (3H-DG) and 3H-3-O-methyl-D-glucose (3H-OMG), and to 14C-sorbitol. Additionally, we tested if gadopentetate dimeglumine administration could prevent any of the changes observed after TBI. Traumatic brain injury induced an increase in the AP-to-BL Papp to 3H-DG. After a 100-min. perfusion of the jejunum, the AP-to-BL Papp to 3H-DG in TBI rats was almost 70% higher than in the control rats. There was no change, however, in the AP-to-BL Papp to neither 3H-OMG nor 14C-sorbitol. Interestingly enough, gadopentetate dimeglumine was able to prevent the increase in the AP-to-BL Papp to 3H-DG observed after TBI. Given the differences in transport characteristics between 3H-DG and 3H-OMG, our results point to the possibility of the Na+-independent glucose transporter 2 (GLUT2) being activated by TBI (as the Papp to 3H-DG, a GLUT2 substrate, was increased) and the Na+-dependent glucose co-transporter (SGLT1) being inhibited by TBI (as the Papp to 3H-OMG, a GLUT2 and SGLT1 substrate, remained unchanged). Moreover, gadopentetate dimeglumine prevented these changes associated with TBI.
- Subjects
BRAIN injuries; BRAIN concussion; BRAIN damage; MORTALITY; TRAUMATIC shock (Pathology); TRAUMATOLOGY; DEATH; CLINICAL pharmacology; TOXICOLOGY
- Publication
Basic & Clinical Pharmacology & Toxicology, 2008, Vol 103, Issue 3, p247
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2008.00272.x