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- Title
Hiding in Plain Sight: Characterization of Aeromonas Species Isolated from a Recreational Estuary Reveals the Carriage and Putative Dissemination of Resistance Genes.
- Authors
Canellas, Anna Luiza Bauer; de Oliveira, Bruno Francesco Rodrigues; Laport, Marinella Silva
- Abstract
Antimicrobial resistance (AMR) has become one of the greatest challenges worldwide, hampering the treatment of a plethora of infections. Indeed, the AMR crisis poses a threat to the achievement of the United Nations' Sustainable Development Goals and, due to its multisectoral character, a holistic approach is needed to tackle this issue. Thus, the investigation of environments beyond the clinic is of utmost importance. Here, we investigated thirteen strains of antimicrobial-resistant Aeromonas isolated from an urban estuary in Brazil. Most strains carried at least one antimicrobial resistance gene and 11 carried at least one heavy metal resistance gene. Noteworthy, four (30.7%) strains carried the blaKPC gene, coding for a carbapenemase. In particular, the whole-genome sequence of Aeromonas hydrophila strain 34SFC-3 was determined, revealing not only the presence of antimicrobial and heavy metal resistance genes but also a versatile virulome repertoire. Mobile genetic elements, including insertion sequences, transposons, integrative conjugative elements, and an IncQ1 plasmid were also detected. Considering the ubiquity of Aeromonas species, their genetic promiscuity, pathogenicity, and intrinsic features to endure environmental stress, our findings reinforce the concept that A. hydrophila truly is a "Jack of all trades" that should not be overlooked under the One Health perspective.
- Subjects
BRAZIL; SUSTAINABLE Development Goals (United Nations); UNITED Nations; MOBILE genetic elements; AEROMONAS; AEROMONAS hydrophila; HORIZONTAL gene transfer; DRUG resistance in microorganisms
- Publication
Antibiotics (2079-6382), 2023, Vol 12, Issue 1, p84
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics12010084