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- Title
Investigation of Tumor Angiogenesis in an Id Mouse Model: Role of Host-Tumor Interactions2.
- Authors
Kreisle, Regina A.; Ershler, William B.
- Abstract
The role of host-tumor interactions in tumor angiogenesis was studied in an id mouse model. Although many previous studies have described the effects of certain host factors (age, nutritional status, tumor location, etc.) on experimental tumor systems, the effects of these factors on tumor angiogenesis have not been reported. In preliminary studies we inoculated cloned tumor cells id into syngeneic mice and found positional differences in tumor growth that did not correlate with measured angiogenesis levels. In addition, while tumor growth was inhibited by radiation, tumor-induced (but not fibroblast-induced) angiogenesis was not. This id system may provide an assay not only for examining the effect of host factors on tumor angiogenesis, but also for elucidation of the mechanisms underlying neovascular induction and host response.
- Publication
JNCI: Journal of the National Cancer Institute, 1988, Vol 80, Issue 11, p849
- ISSN
0027-8874
- Publication type
Article