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- Title
One-year results of anti-vascular endothelial growth factor therapy combined with triamcinolone acetonide for macular edema associated with branch retinal vein occlusion.
- Authors
Osaka, Rie; Muraoka, Yuki; Nakano, Yuki; Takasago, Yukari; Koyama, Yuta; Miyoshi, Yukiko; Tsujikawa, Akitaka; Suzuma, Kiyoshi
- Abstract
Purpose: To compare anti-vascular endothelial growth factor (anti-VEGF) monotherapy with anti-VEGF therapy combined with sub-Tenon's capsule injections of triamcinolone acetonide (STTA) in patients with macular edema (ME) associated with branch retinal vein occlusion (BRVO). Study design: Retrospective observational study Methods: This study included 186 eyes: 138 eyes received intravitreal injection of ranibizumab (IVR), and the remaining 48 eyes received IVR combined with STTA therapy. If additional IVR were necessary, STTA were performed simultaneously. Results: Both groups showed a rapid reduction in ME. The changes in logMAR visual acuity (VA) from baseline to 12 months were − 0.26 ± 0.26 in the IVR and − 0.20 ± 0.26 in the IVR with STTA groups (P = 0.209). The changes in mean central foveal thickness from baseline to 12 months were − 226.9 ± 208.2 µm in the IVR and − 236.0 ± 214.0 µm in the IVR with STTA groups (P = 0.798). The required number of IVR was 3.4 ± 1.9 in the IVR group, and 3.4 ± 1.6 in the IVR and STTA group (P = 0.950). There were no significant differences in any parameters between the two groups. Conclusion: There were no clear differences between combination therapy of anti-VEGF with STTA and anti-VEGF monotherapy for the treatment of patients with ME associated with BRVO. The number of anti-VEGF injections in patients who received the combination therapy was not reduced as compared with the number of anti-VEGF injections in patients who received the monotherapy.
- Subjects
RETINAL vein occlusion; ENDOTHELIAL growth factors; TRIAMCINOLONE acetonide; EDEMA; VISUAL acuity
- Publication
Japanese Journal of Ophthalmology, 2020, Vol 64, Issue 6, p605
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-020-00765-w