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- Title
Interocular symmetry of the foveal avascular zone area in healthy eyes: a swept-source optical coherence tomography angiography study.
- Authors
Liu, Mengxuan; Fujiwara, Atsushi; Morizane, Yuki; Kawasaki, Ryo; Kimura, Shuhei; Morizane-Hosokawa, Mio; Shiode, Yusuke; Hirano, Masayuki; Doi, Shinichiro; Toshima, Shinji; Takahashi, Kosuke; Hosogi, Mika; Ma, Xiang; Shiraga, Fumio
- Abstract
Purpose: To determine the presence or absence of interocular differences in the foveal avascular zone (FAZ) area in healthy eyes. Study design: Cross-sectional study. Methods: We examined 236 healthy eyes of 118 consecutive subjects (mean age, 39.1 ± 18.9 years). We used swept-source optical coherence tomography angiography (OCTA) images of the FAZ to measure its area from both the superficial capillary plexus (SCP-FAZ) and the whole retinal capillary plexus (WCP-FAZ). We also investigated the relationship between interocular differences in SCP-FAZ and other factors such as: axial length, spherical equivalent, central retinal thickness, and retinal vascular density. Results: There was no significant difference in the FAZ area between the right and left eyes in either the SCP-FAZ (P = 0.61) or WCP-FAZ (P = 0.80), and the FAZ areas of both eyes showed significant positive correlations (SCP-FAZ; P < 0.001, R2 = 0.884, WCP-FAZ; P < 0.001, R2 = 0.856). Bland–Altman plots showed that the mean interocular difference in SCP-FAZ area was 0.002 ± 0.037 mm2 (95% confidence interval, -0.072–0.075 mm2), and in the WCP-FAZ area, 0.050 ± 0.044 mm2 (95% confidence interval, -0.036–0.137 mm2). Multivariate regression analysis showed that none of the investigated factors were significantly associated with interocular differences in SCP-FAZ (P = 0.61, R2 = 0.138). Conclusions: There was no significant interocular difference in SCP- and WCP-FAZ areas in healthy eyes. The normal range of values for interocular difference in SCP-FAZ area was 0.002 ± 0.037 mm2 and in the WCP-FAZ area, 0.050 ± 0.044 mm2.
- Subjects
OPTICAL coherence tomography; EYE; BLAND-Altman plot; SYMMETRY; REGRESSION analysis
- Publication
Japanese Journal of Ophthalmology, 2020, Vol 64, Issue 2, p171
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-020-00719-2