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- Title
Additive effects of orthokeratology and atropine 0.01% ophthalmic solution in slowing axial elongation in children with myopia: first year results.
- Authors
Kinoshita, Nozomi; Konno, Yasuhiro; Hamada, Naoki; Kanda, Yoshinobu; Shimmura-Tomita, Machiko; Kakehashi, Akihiro
- Abstract
Purpose: To investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial elongation in children with myopia.Study design: Prospective randomized clinical trial.Methods: Japanese children aged 8-12 years with a spherical equivalent refractive error of − 1.00 to − 6.00 diopters were included. A total of 41 participants who had been wearing the OK lenses successfully for 3 months were randomly allocated into two groups to receive either the combination of OK and atropine 0.01% ophthalmic solution (combination group) or monotherapy with OK (monotherapy group). Subjects in the combination group started to use atropine 0.01% ophthalmic solution once nightly from 3 months after the start of OK. Axial length was measured every 3 months using non-contact laser interferometry (IOLMaster), and the axial length measurement at month 3 of OK therapy was used as the baseline value in both groups. The increase in axial length over 1 year was compared between the two groups.Results: A total of 40 consecutive subjects (20 subjects in the combination group and 20 in the monotherapy group) were followed for 1 year. The increase in axial length over 1 year was 0.09 ± 0.12 mm in the combination group and 0.19 ± 0.15 mm in the monotherapy group (P = 0.0356, unpaired t test).Conclusion: During the 1-year follow-up, the combination of OK and atropine 0.01% ophthalmic solution was more effective in slowing axial elongation than OK monotherapy in children with myopia.
- Subjects
DRUG additives; ORTHOKERATOLOGY; ATROPINE; MYOPIA; LASER interferometry; PATIENTS; THERAPEUTICS
- Publication
Japanese Journal of Ophthalmology, 2018, Vol 62, Issue 5, p544
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-018-0608-3