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- Title
Inhibition of choroidal neovascularization by blocking vascular endothelial growth factor receptor tyrosine kinase.
- Authors
Junko Kami; Kimimasa Muranaka; Yasuo Yanagi; Ryo Obata; Yasuhiro Tamaki; Masabumi Shibuya
- Abstract
Abstract Purpose  To investigate the role played by receptors of vascular endothelial growth factors, Flt-1 and KDR/Flk-1, on an experimental model of choroidal neovascularization (CNV). Methods  The vascular endothelial growth factor-A (VEGF-A) receptor-specific tyrosine kinase inhibitor SU5416 was administered to a laser-induced mouse model of CNV. The formation of CNV and the degree of vascular permeability in Flt-1 tyrosine kinase domain-deficient mice were also investigated. Results  SU5416 reduced vascularity and vascular endothelial cell proliferation, and promoted endothelial cell apoptosis within CNV. Furthermore, the formation of CNV and the degree of vascular permeability were significantly reduced in Flt-1 tyrosine kinase domain-deficient mice, and this effect was enhanced by the administration of SU5416. Conclusions  Both Flt-1 and KDR/Flk-1 have a significant role in CNV formation. Suppression of apoptosis may be involved in the process.
- Subjects
NEOVASCULARIZATION; CHOROID; VASCULAR endothelial growth factors; PROTEIN-tyrosine kinases; CELL proliferation
- Publication
Japanese Journal of Ophthalmology, 2008, Vol 52, Issue 2, p91
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-007-0506-6