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- Title
An fMRI Marker for Peripheral Nerve Regeneration.
- Authors
Rath, Jakob; Klinger, Nicolaus; Geißler, Alexander; Höllinger, Ilse; Gruber, Susanne; Wurnig, Moritz; Hausner, Thomas; Auff, Eduard; Schmidhammer, Robert; Beisteiner, Roland
- Abstract
Final outcome after surgical repair of peripheral nerve transections varies. Here, we present the first longitudinal functional magnetic resonance imaging (fMRI) obserof cortical somatosensory reorganization patterns after surgery. A 43-year-old man presented with isolated complete transecof the right median nerve and underwent immediate epineural end-to-end coaptation. Applying standardized vibrotactile median nerve stimulation, 3 T brain activation maps were evaluated at 1, 7, 15 weeks and 1 year after surgery. Initially, the affected hemisphere showed no primary activation but increased frontoparietal activity. After 1 year, primary activation had recovered, and frontoparietal activity was decreased relative to the nonaffected hemisphere. Based on these longitudinal fMRI patterns, we propose a new marker for restoration of somatosensory function, which may not be provided by electrophysiological methods.
- Subjects
AUSTRIA; BRAIN physiology; MEDIAN nerve surgery; MEDIAN nerve injuries; MEDIAN nerve; ANALYSIS of variance; COMPUTER software; EXERCISE tests; LONGITUDINAL method; MAGNETIC resonance imaging; MEDICAL rehabilitation; MOTOR ability; MUSCLE contraction; NERVOUS system regeneration; NEUROSURGERY; NEUROLOGIC examination; NEUROPLASTICITY; PATIENTS; PROBABILITY theory; REGRESSION analysis; RESEARCH funding; SOMATOSENSORY evoked potentials; DATA analysis; REPEATED measures design; PHYSIOLOGY
- Publication
Neurorehabilitation & Neural Repair, 2011, Vol 25, Issue 6, p577
- ISSN
1545-9683
- Publication type
Article
- DOI
10.1177/1545968310397552