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- Title
Research progress of microRNA in regulating osteoblast proliferation and apoptosis.
- Authors
FENG Zhengping; LI Jiling
- Abstract
microRNA (miRNA) is a class of non-coding small RNA that plays an important role in regulating the gene expression. miRNA participates in the gene regulation at the post-ranscriptional level by binding to target the mRNA, resulting in degradation of the target mRNA or in inhibition of its translation, thereby controlling the cell proliferation, differentiation, and apoptosis, and consequently involves in the development and progression of diseases. The osteoblast is a key member in bone formation. Bone metabolism is closely related to the change of osteoblast number or function. Recently, the relationship between miRNA and bone metabolism has been concerned mostly. Many studies have shown that miRNA plays an important regulatory role in the differentiation of osteoblast. However, the research of miRNA in regulating the proliferation and apoptosis of osteoblast is relatively little. This paper reviews the research progress of miRNA in regulation of osteoblast proliferation and apoptosis.
- Publication
Chinese Journal of Osteoporosis, 2015, Vol 21, Issue 4, p499
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2015.04.024