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- Title
A fresh look at the role of spiramycin in preventing a neglected disease: meta-analyses of observational studies.
- Authors
Montoya, Jose G.; Laessig, Katherine; Fazeli, Mir Sohail; Siliman, Gaye; Yoon, Sophie S.; Drake-Shanahan, Elizabeth; Zhu, Chengyue; Akbary, Akbar; McLeod, Rima
- Abstract
Purpose: We aimed to investigate the effect of antepartum treatment with spiramycin with or without subsequent pyrimethamine–sulfonamide–folinic acid, compared to no treatment, on the rate of mother-to-child transmission (MTCT) of Toxoplasma gondii (T. gondii) and incidence/severity of sequelae in the offspring. Methods: Embase and PubMed were searched for literature on spiramycin in pregnant women suspected/diagnosed with T. gondii infection. Meta-analyses were performed using random-effects model. Results: Thirty-three studies (32 cohorts and 1 cross-sectional study), with a total of 15,406 mothers and 15,250 offspring, were pooled for analyses. The MTCT rate for all treated patients was significantly lower than the untreated [19.5% (95% CI 14–25.5%) versus 50.7% (95% CI 31.2–70%), p < 0.001]. The transmission rate in patients on spiramycin monotherapy was also significantly lower than untreated [17.6% (95% CI 9.9–26.8%) versus 50.7% (95% CI 31.2–70%), p < 0.001]. Conclusion: Results indicate significant reduction in MTCT rates following spiramycin treatment of suspected/diagnosed maternal T. gondii infection.
- Subjects
NEGLECTED diseases; SCIENTIFIC observation; DIAGNOSIS; PREGNANT women; TOXOPLASMA gondii; INFECTION
- Publication
European Journal of Medical Research, 2021, Vol 26, Issue 1, p1
- ISSN
0949-2321
- Publication type
Article
- DOI
10.1186/s40001-021-00606-7