We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Microbiota-Related Metabolites and the Risk of Type 2 Diabetes.
- Authors
Vangipurapu, Jagadish; Silva, Lilian Fernandes; Kuulasmaa, Teemu; Smith, Ulf; Markku Laakso; Fernandes Silva, Lilian; Laakso, Markku
- Abstract
<bold>Objective: </bold>Recent studies have highlighted the significance of the microbiome in human health and disease. Changes in the metabolites produced by microbiota have been implicated in several diseases. Our objective was to identify microbiome metabolites that are associated with type 2 diabetes.<bold>Research Design and Methods: </bold>Our study included 5,181 participants from the cross-sectional Metabolic Syndrome in Men (METSIM) study that included Finnish men (age 57 ± 7 years, BMI 26.5 ± 3.5 kg/m2) having metabolomics data available. Metabolomics analysis was performed based on fasting plasma samples. On the basis of an oral glucose tolerance test, Matsuda ISI and disposition index values were calculated as markers of insulin sensitivity and insulin secretion. A total of 4,851 participants had a 7.4-year follow-up visit, and 522 participants developed type 2 diabetes.<bold>Results: </bold>Creatine, 1-palmitoleoylglycerol (16:1), urate, 2-hydroxybutyrate/2-hydroxyisobutyrate, xanthine, xanthurenate, kynurenate, 3-(4-hydroxyphenyl)lactate, 1-oleoylglycerol (18:1), 1-myristoylglycerol (14:0), dimethylglycine, and 2-hydroxyhippurate (salicylurate) were significantly associated with an increased risk of type 2 diabetes. These metabolites were associated with decreased insulin secretion or insulin sensitivity or both. Among the metabolites that were associated with a decreased risk of type 2 diabetes, 1-linoleoylglycerophosphocholine (18:2) significantly reduced the risk of type 2 diabetes.<bold>Conclusions: </bold>Several novel and previously reported microbial metabolites related to the gut microbiota were associated with an increased risk of incident type 2 diabetes, and they were also associated with decreased insulin secretion and insulin sensitivity. Microbial metabolites are important biomarkers for the risk of type 2 diabetes.
- Subjects
FINLAND; TYPE 2 diabetes; MICROBIAL metabolites; METABOLITES; GLUCOSE tolerance tests; INSULIN resistance; BIOCHEMISTRY; CROSS-sectional method; METABOLISM; DISEASE incidence; BLOOD sugar
- Publication
Diabetes Care, 2020, Vol 43, Issue 6, p1319
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc19-2533