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- Title
Visualization of dendritic cells’ responses in atopic dermatitis: Preventing effect of emollient.
- Authors
Mias, Céline; Le Digabel, Jimmy; Filiol, Jérôme; Gontier, Etienne; Gravier, Eléonore; Villaret, Aurélie; Nocera, Thérèse; Questel, Emmanuel; Rossi, Ana‐Beatris; Redoulès, Daniel; Josse, Gwendal
- Abstract
Abstract: Atopic dermatitis (AD) is a chronic and multifactorial inflammatory skin disease involving various dendritic cells such as epidermal Langerhans cells (LC) and inflammatory dendritic epidermal cells (IDECs). Most of the clinical studies was performed on isolated cells, and thus, it would be useful to characterize directly on the human epidermal tissue the first cellular events occurred during the AD. The suction blister method was used to obtain whole epidermis samples and interstitial cutaneous fluids. Employing multiphoton microscopy, we analyzed the early dynamic behavior of inflammatory cells using <italic>Dermatophagoides pteronyssinus</italic> atopy patch test (Derp‐APT) and evaluated the effects of emollient pre‐application. Derp‐APT application provoked rapid and strong infiltration of IDECs, and proliferation and activation of LC in the AD subjects’ epidermis. Moreover, emollient pre‐application strengthened the defective skin barrier and had positive effects on inflammatory cells’ behavior, characterized by the complete inhibition of IDEC influx and the presence of immature LC.
- Subjects
ATOPIC dermatitis treatment; ATOPIC dermatitis; SKIN care; PATIENTS
- Publication
Experimental Dermatology, 2018, Vol 27, Issue 4, p374
- ISSN
0906-6705
- Publication type
Letter to the Editor
- DOI
10.1111/exd.13470