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- Title
Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients.
- Authors
Torii, Kan; Saito, Chiyo; Furuhashi, Takuya; Nishioka, Akiko; Shintani, Yoichi; Kawashima, Kana; Kato, Hiroshi; Morita, Akimichi
- Abstract
Environmental factors contribute to the increased prevalence of autoimmune diseases via T helper type-17 cell (Th17) activation. Tobacco smoking increases the risk of psoriasis, but the mechanisms are not clear. We evaluated the percentage of circulating Th17 among CD3 cells in peripheral blood mononuclear cells (PBMC) obtained from 27 healthy volunteers (2.58 ± 0.80%), 33 smoker (3.55 ± 1.33%) and 21 non-smoker (3.10 ± 1.14%) patients with psoriasis to elucidate the relation between smoking and psoriasis. More smokers (19/33) than non-smokers (6/21) had high Th17 levels (Th17/CD3 > 3.38%, mean + 1 SD of healthy volunteers). Tobacco smoke extract (TSE, 7 μl/ml) induced Th17 generation from central memory T cells in vitro. TSE increased interleukin 17 and 22 expression. These findings demonstrate the relation between tobacco smoke and IL-17 and IL-22, which exacerbate psoriasis.
- Subjects
LETTERS to the editor; PSORIASIS; TOBACCO smoke; PATIENTS
- Publication
Experimental Dermatology, 2011, Vol 20, Issue 4, p371
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/j.1600-0625.2010.01224.x