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- Title
The impact of chronic hepatitis C and co-morbid illnesses on health-related quality of life.
- Authors
Kwan, Jeffrey W.; Cronkite, Ruth C.; Yiu, Antony; Goldstein, Mary K.; Kazis, Lewis; Cheung, Ramsey C.
- Abstract
Determine the relative impact of chronic hepatitis C (CHC) and co-morbid illnesses on health-related quality of life (HRQoL) in 3023 randomly selected veterans with known hepatitis C virus antibody (anti-HCV) status who previously completed a veteran-specific HRQoL questionnaire (SF-36V). Multiple regression analyses were performed to measure the relative contribution of anti-HCV status, four demographic variables, and ten common medical and six psychiatric co-morbidities to HRQoL between 303 anti-HCV(+) and 2720 anti-HCV(−) patients. Anti-HCV(+) veterans were younger, reported a lower HRQoL on seven of eight 36-Item Short Form Health Survey for Veterans (SF-36V) subscales ( P ≤ 0.001) and the mental component summary (MCS) scale ( P < 0.001). The ten medical and six psychiatric co-morbidities had variable impact on predicting lower HRQoL in both groups. After adjusting for demographic variables and co-morbid illnesses, we found that anti-HCV(+) patients reported a significantly lower MCS score ( P < 0.001) and a trend toward a lower physical component summary (PCS) score ( P < 0.07) compared to anti-HCV(−) veterans. Among the anti-HCV(+) veterans, co-morbid medical illnesses contributed to impaired PCS but not to MCS. Veterans with CHC were younger than HCV(−) veterans and hence less likely to have other co-morbid medical illnesses. Medical co-morbidities seen in those veterans with CHC contribute to impaired PCS but not MCS. Anti-HCV(+) status negatively affects HRQoL, particularly MCS, independently of medical and psychiatric co-morbidities.
- Subjects
HEPATITIS C virus; LIVER diseases; QUALITY of life; DISEASES in veterans; MULTIPLE regression analysis; HEALTH surveys
- Publication
Quality of Life Research, 2008, Vol 17, Issue 5, p715
- ISSN
0962-9343
- Publication type
Article
- DOI
10.1007/s11136-008-9344-3