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- Title
In Vitro Antimicrobial, Antiproliferative, and Antioxidant Activities of Bis Pyrrolizidine Fused Dispiro Oxindolo Curcuminoids.
- Authors
Bharitkar, Yogesh P.; Datta, Suhana; Sett, Saurov; Marathee, Neeraja; Khan, Preeti; Hazra, Abhijit; Singh, Meenakshi; Sahoo, Ashutosh; Ghosh, Shekhar; Mondal, Susanta; Mitra, Arup K.; V., Ravichandiran; Mondal, Nirup B.
- Abstract
Curcumin has been transformed to racemic/meso curcuminoids via an azomethine ylide cycloaddition reaction using isatin/acenaphthoquinone and proline. The resulting analogues were subjected to screening of antimicrobial efficacy against some opportunistic pathogenic bacteria (B. subtilis, E. coli, P. aeruginosa, S. aureus) and the potent ones (4Dd, 4Ed, 4Fb and 4Fd) were assessed for growth curve assay and biomolecular damages. Cytotoxicity studies against six cell lines (Caco-2, MDCK-2, CHO-K1, HEK-293, Hela and HepG-2) revealed that IC50 values of some derivatives (3Ab, 4Ba, 4Bb, 4Da, 4Db and 4Fc) were markedly lower than those of curcumin in all the six cell lines, the products being most potent against Hek-293, Hela, and Hep-G2. DPPH radical scavenging activity showed significant antioxidant potential in these analogues compared to curcumin.
- Subjects
PYRROLIZIDINES; CURCUMINOIDS; RING formation (Chemistry); ANTI-infective agents; DRUG efficacy; CELL-mediated cytotoxicity; ANTIOXIDANTS; GROWTH curves (Statistics)
- Publication
Chemistry & Biology Interface, 2017, Vol 7, Issue 1, p19
- ISSN
2249-4820
- Publication type
Article