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- Title
Arachis hypogaea L. stem and leaf extract improves the sleep behavior of pentobarbital-treated rats.
- Authors
XIAO-YAN ZU; GUANG-QUAN XIONG; SHENG-RONG GENG; TAO LIAO; XIN LI; ZHEN-YA ZHANG
- Abstract
This study was conducted to evaluate the sedative effects of Arachis hypogaea L. stem and leaf extract (AHSLE) and determine its effect pathways through γ-aminobutyric acid (GABA)-gated channels on male Sprague-Dawley rats treated with pentobarbital. AHSLE was obtained from 98°C water (3 h, extracted twice). AHSLE and flumazenil (a GABA type A receptor antagonist) were administered to the rats orally, whereas pentobarbital sodium and muscimol (a GABA type A receptor agonist) were administered intraperitoneally (i.p.). The results demonstrated that AHSLE decreased sleep latency and increased sleep time in pentobarbital-treated rats (50 mg/kg, i.p.). The coadministration of AHSLE and muscimol (0.05 mg/kg) significantly increased sleep time and reduced sleep latency in pentobarbital-treated rats and these actions were significantly antagonized by flumazenil at a dose of 3.5 mg/kg. These results indicated that AHSLE improved the sleep behavior in pentobarbital-treated rats, possibly through GABA-gated channel-related mechanisms.
- Subjects
PEANUT research; EXTRACTS; PENTOBARBITAL; SLEEP behavior in animals; SEDATIVES; GABA; PHARMACODYNAMICS; THERAPEUTICS
- Publication
Biomedical Reports, 2014, Vol 2, Issue 3, p388
- ISSN
2049-9434
- Publication type
Article
- DOI
10.3892/br.2014.259