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- Title
High prevalence of willingness to use direct-acting antiviral-based regimens for hepatitis C virus ( HCV) infection among HIV/ HCV coinfected people who use drugs.
- Authors
Socías, ME; Ti, L; Dong, H; Shoveller, J; Kerr, T; Montaner, J; Milloy, M‐J
- Abstract
Objectives Despite the high burden of hepatitis C virus ( HCV)-related morbidity and mortality among HIV-positive people who use illicit drugs ( PWUD), uptake of interferon-based treatments for HCV infection has been negligible among this group. Direct-acting antiviral ( DAA) therapies offer an opportunity to expand treatment access among this population. The aim of this study was to explore willingness to use DAA-based regimens among HIV/ HCV-coinfected PWUD in Vancouver, Canada. Methods Data were drawn from the AIDS Care Cohort to evaluate Exposure to Survival Services ( ACCESS), a prospective cohort of HIV-positive PWUD. Using logistic regression analyses, we investigated factors associated with willingness to use DAA-based regimens among HIV/ HCV-coinfected participants. Results Of 418 HIV/ HCV-coinfected PWUD surveyed between June 2014 and May 2015, 295 (71%) were willing to use DAA-based regimens. In multivariable analysis, participants enrolled in methadone maintenance therapy [adjusted odds ratio ( AOR) 1.61; 95% confidence interval ( CI) 1.04-2.51], those with a recent assessment by an HCV specialist ( AOR 2.02; 95% CI 1.28-3.19) and those who perceived that HCV infection was affecting their health ( AOR 2.49; 95% CI 1.41-4.37) were more likely to be willing to use DAA-based regimens. Conclusions Overall, this study found a high prevalence of willingness to use DAA-based regimens among HIV/ HCV-coinfected PWUD in Vancouver. Importantly, enrolment in methadone maintenance therapy was positively associated with willingness, suggesting that integrated models of HIV, HCV and addiction care should be explored as a way to address HCV-related morbidity and mortality among HIV/ HCV-coinfected PWUD.
- Subjects
CANADA; ANTIVIRAL agents; CONFIDENCE intervals; HIV infections; PSYCHOLOGY of HIV-positive persons; PROBABILITY theory; LOGISTIC regression analysis; SECONDARY analysis; DRUG abusers; PATIENTS' attitudes; CHRONIC hepatitis C; ODDS ratio; MIXED infections
- Publication
HIV Medicine, 2017, Vol 18, Issue 9, p647
- ISSN
1464-2662
- Publication type
Article
- DOI
10.1111/hiv.12501