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- Title
B‐DNA Structure and Stability: The Role of Nucleotide Composition and Order.
- Authors
Nieuwland, Celine; Hamlin, Trevor A.; Fonseca Guerra, Célia; Barone, Giampaolo; Bickelhaupt, F. Matthias
- Abstract
Invited for this month's cover are the groups of Célia Fonseca Guerra at the Vrije Universiteit Amsterdam and Leiden University, Giampaolo Barone from the Università degli Studi di Palermo, and F. Matthias Bickelhaupt at Vrije Universiteit Amsterdam and Radboud University Nijmegen. The cover picture shows the four primary interaction components (hydrogen bonding, cross‐terms, base stacking, and solvation) that determine the stability of B‐DNA duplexes. Quantum chemical analyses identify an interplay between the stabilizing hydrogen bonds between nucleotides that drive the formation of the DNA double‐strand, and the destabilizing loss of stacking interactions within individual strands combined with partial desolvation. The sequence‐dependence in the duplex stability originates mainly from the cross‐terms, which can be attractive or repulsive. Read the full text of their Research Article at10.1002/open.202100231.
- Subjects
RADBOUD Universiteit Nijmegen; RIJKSUNIVERSITEIT te Leiden; STACKING interactions; ANALYTICAL chemistry; HYDROGEN bonding; TEXT files; NUCLEOTIDES
- Publication
ChemistryOpen, 2022, Vol 11, Issue 2, p1
- ISSN
2191-1363
- Publication type
Article
- DOI
10.1002/open.202100231