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- Title
Glutathione peroxidase‐1 gene rescues cocaine‐induced conditioned place preference in mice by inhibiting σ‐1 receptor expression.
- Authors
Pham, Duc Toan; Chung, Yoon Hee; Mai, Huynh Nhu; Sharma, Naveen; Yun, Jaesuk; Kim, Hee Jin; Cheong, Jae Hoon; Jeong, Ji Hoon; Kim, Dae‐Joong; Shin, Eun‐Joo; Kim, Hyoung‐Chun
- Abstract
The aim of this study was to investigate whether the glutathione peroxidase‐1 gene (GPx‐1) affects cocaine‐induced conditioned place preference (CPP) using a mouse model. Cocaine‐induced CPP was accompanied by an increase in the level of σ‐1 receptor in the nucleus accumbens (NAc). This phenomenon was more pronounced in the GPx‐1 gene knockout (GPx‐1 KO) than in wild type (WT) mice. In contrast, the CPP and expression of σ‐1 receptor were much less pronounced in GPx‐1‐overexpressing transgenic (GPx‐1 TG) mice than non‐transgenic (non‐TG) mice. Treatment of the mice with BD1047, a σ‐1 receptor antagonist, significantly attenuated both cocaine‐induced CPP and c‐Fos‐immunoreactivity (c‐Fos‐IR) in WT and GPx‐1 KO mice, although the effects were more evident in the latter group. Despite the protective effects of BD1047 on cocaine‐induced CPP and c‐Fos in non‐TG mice, there were no additional protective effects in cocaine‐treated GPx‐1 TG mice, indicating that the σ‐1 receptor is a critical target for GPx‐1‐mediated psychoprotective activity. Overall, our results suggest that GPx‐1 attenuates cocaine‐induced CPP via inhibition of σ‐1 receptor expression.
- Subjects
MICE; NUCLEUS accumbens; GENE knockout; GLUTATHIONE; CONSUMER preferences; GLUTATHIONE peroxidase; GENES
- Publication
Clinical & Experimental Pharmacology & Physiology, 2019, Vol 46, Issue 9, p791
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1111/1440-1681.13140