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- Title
Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography.
- Authors
Sokolov, Alexey Y.; Volynsky, Maxim A.; Potapenko, Anastasiia V.; Iurkova, Polina M.; Zaytsev, Valeriy V.; Nippolainen, Ervin; Kamshilin, Alexei A.
- Abstract
Among numerous approaches to the study of migraine, the nitroglycerin (NTG) model occupies a prominent place, but there is relatively insufficient information about how NTG affects intracranial vessels. In this study we aim to assess the effects of NTG on blood-flow parameters in meningeal vessels measured by imaging photoplethysmography (iPPG) in animal experiments. An amplitude of the pulsatile component (APC) of iPPG waveform was assessed before and within 2.5 h after the NTG administration in saline (n = 13) or sumatriptan (n = 12) pretreatment anesthetized rats in conditions of a closed cranial window. In animals of both groups, NTG caused a steady decrease in blood pressure. In 7 rats of the saline group, NTG resulted in progressive increase in APC, whereas decrease in APC was observed in other 6 rats. In all animals in the sumatriptan group, NTG administration was accompanied exclusively by an increase in APC. Diametrically opposite changes in APC due to NTG indicate a dual effect of this drug on meningeal vasomotor activity. Sumatriptan acts as a synergist of the NTG vasodilating action. The results we obtained contribute to understanding the interaction of vasoactive drugs in the study of the headache pathophysiology and methods of its therapy.
- Subjects
PHOTOPLETHYSMOGRAPHY; RATS; NITROGLYCERIN; ANIMAL experimentation; BLOOD pressure; SUMATRIPTAN; SPREADING cortical depression
- Publication
Scientific Reports, 2023, Vol 13, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-023-39171-w