We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Shiga Toxin-Associated Hemolytic Uremic Syndrome in Adults, France, 2009-2017.
- Authors
Travert, Benoît; Dossier, Antoine; Jamme, Matthieu; Cointe, Aurélie; Delmas, Yahsou; Malot, Sandrine; Wynckel, Alain; Seguin, Amélie; Presne, Claire; Hie, Miguel; Benhamou, Ygal; Ribes, David; Choukroun, Gabriel; Grangé, Steven; Hertig, Alexandre; Cornec-Le Gall, Emilie; Galicier, Lionel; Daugas, Eric; Bouadma, Lila; Weill, François-Xavier
- Abstract
We conducted a retrospective study on hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli (STEC) in 96 adults enrolled in the cohort of the National Reference Center for Thrombotic Microangiopathies network in France during 2009-2017. Most infections were caused by STEC strains not belonging to the O157 or O104 serogroups. Thirty (31.3%) patients had multiple risk factors for thrombotic microangiopathy. In total, 61 (63.5%) patients required dialysis, 50 (52.1%) had a serious neurologic complication, 34 (35.4%) required mechanical ventilation, and 19 (19.8%) died during hospitalization. We used multivariate analysis to determine that the greatest risk factors for death were underlying immunodeficiency (hazard ratio 3.54) and severe neurologic events (hazard ratio 3.40). According to multivariate analysis and propensity score-matching, eculizumab treatment was not associated with survival. We found that underlying conditions, especially immunodeficiency, are strongly associated with decreased survival in adults who have hemolytic uremic syndrome caused by STEC.
- Subjects
FRANCE; HEMOLYTIC-uremic syndrome; THROMBOTIC thrombocytopenic purpura; ADULTS; MULTIVARIATE analysis; ARTIFICIAL respiration; ESCHERICHIA coli; RESEARCH; RESEARCH methodology; RETROSPECTIVE studies; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; ESCHERICHIA coli diseases; BACTERIAL toxins
- Publication
Emerging Infectious Diseases, 2021, Vol 27, Issue 7, p1876
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2707.204638