We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Rare Detection of Bordetella pertussis Pertactin-Deficient Strains in Argentina.
- Authors
Carriquiriborde, Francisco; Regidor, Victoria; Aispuro, Pablo M.; Magali, Gabrielli; Bartel, Erika; Bottero, Daniela; Hozbor, Daniela
- Abstract
Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine.
- Subjects
ARGENTINA; BUENOS Aires (Argentina : Province); BORDETELLA pertussis; WHOOPING cough vaccines; WHOOPING cough; PUBLIC health surveillance; RESEARCH; GENETIC mutation; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; SEROTYPES; COMPARATIVE studies; GENOTYPES; MEMBRANE proteins; BACTERIAL toxins
- Publication
Emerging Infectious Diseases, 2019, Vol 25, Issue 11, p2048
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2511.190329