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- Title
17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil.
- Authors
Campi-Azevedo, Ana Carolina; Peruhype-Magalhāes, Vanessa; Coelho-dos-Reis, Jordana Grazziela; Antonelli, Lis Ribeiro; Costa-Pereira, Christiane; Speziali, Elaine; Reis, Laise Rodrigues; Lemos, Jandira Aparecida; Leite Ribeiro, José Geraldo; Camacho, Luiz Antônio Bastos; de Sousa Maia, Maria de Lourdes; de Lima, Sheila Maria Barbosa; Simões, Marisol; de Menezes Martins, Reinaldo; Homma, Akira; Malaquias, Luiz Cosme Cota; Luiz Tauil, Pedro; Costa Vasconcelos, Pedro Fernando; Romano, Alessandro Pecego Martins; Domingues, Carla Magda
- Abstract
We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine-specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-γ+CD8+ T cells, 10 years after primary vaccination. Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-γ+CD8+ T cells. Moreover, secondary or multiple vaccinations guarantee long-term persistence of PRNT positivity and cell-mediated memory 10 years after booster vaccination. These findings support the relevance of booster doses to heighten the 17DD-YF-specific immune response to guarantee the long-term persistence of memory components. Secondary or multiple vaccinations improved the correlates of protection triggered by 17DD-YF primary vaccination, indicating that booster regimens are needed to achieve efficient immunity in areas with high risk for virus transmission.
- Subjects
BRAZIL; YELLOW fever; HERD immunity; LONG-term memory; T cells; NEUTRALIZATION tests; PERSISTENCE
- Publication
Emerging Infectious Diseases, 2019, Vol 25, Issue 8, p1511
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2508.181432