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- Title
Euonymus alatus in the Treatment of Diabetic Nephropathy in Rats.
- Authors
Chang, Bai; Jin, Chuan; Zhang, Wei; Kong, Li; Yang, Ju-Hong; Lian, Feng-Mei; Li, Qiao-Fen; Yu, Bo; Liu, Wen-Ke; Yang, Ling-Ling; Zhao, Ping; Zhen, Zhong
- Abstract
Diabetic nephropathy is a leading cause of chronic renal failure. Recently, Euonymus alatus showed therapeutic potential in the treatment of diabetes and its chronic complications. In this study, effects of Euonymus alatus and its mechanism in the treatment of diabetic nephropathy were investigated. Diabetic nephropathy was induced in Sprague-Dawley rats by uninephrectomy plus streptozotocin (STZ) administration. Euonymus alatus and irbesartan, as a positive control, were lavaged to these rats for 12 weeks. Our data showed that Euonymus alatus was efficient in lowering HbA1c, improving blood lipids, decreasing 24 h urine protein and protecting kidney function. Pathological studies found kidney damage, including extracellular matrix expansion and glomerulosclerosis, were improved by Euonymus alatus treatment. Further investigation found that the herb had a role in downregulating the expression of transform growth factor β1. In conclusion, Euonymus alatus has a protective role in diabetic nephropathy, which may be related to its downregulation of transform growth factor β1 expression.
- Subjects
THERAPEUTIC use of plant extracts; ANALYSIS of variance; ANIMAL experimentation; DIABETES; DIABETIC nephropathies; GLYCOSYLATED hemoglobin; GROWTH factors; KIDNEYS; LIPIDS; POLYMERASE chain reaction; RATS; RESEARCH funding; URINALYSIS; REVERSE transcriptase polymerase chain reaction; IRBESARTAN; DATA analysis software; DESCRIPTIVE statistics
- Publication
American Journal of Chinese Medicine, 2012, Vol 40, Issue 6, p1177
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X12500875