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- Title
The influence of patient demographics, disease characteristics and treatment on brain volume loss in Trial Assessing Injectable Interferon vs FTY720 Oral in Relapsing–Remitting Multiple Sclerosis (TRANSFORMS), a phase 3 study of fingolimod in ...
- Authors
Barkhof, Frederik; de Jong, Remko; Sfikas, Nikolaos; de Vera, Ana; Francis, Gordon; Cohen, Jeffrey
- Abstract
The article presents a study which examines the effect of treatment on brain volume (BV) loss of multiple sclerosis (MS). The study assesses the effect of fingolimod and intramuscular (IM) interferon β-1a (IFNβ-1a) on the on-study percentage BV change (PBVC) according to patient demographics, disease, and magnetic resonance imaging (MRI). Result shows that fingolimod and IFNβ-1a IM can reduce BV loss in all the subgroup of patients assessed.
- Subjects
MULTIPLE sclerosis treatment; FINGOLIMOD; MAGNETIC resonance imaging; INTERFERON beta-1a; BRAIN physiology; TREATMENT effectiveness
- Publication
Multiple Sclerosis Journal, 2014, Vol 20, Issue 13, p1704
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458514532317