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- Title
Kinetic Parameters of α<sub>2</sub>-macroglobulin in Rats Induced Nephropathy by Administration of Gentamicin.
- Authors
Takashi Kuribayashi
- Abstract
The elimination phase of α2-macroglobulin (α2M), a typical acute phase protein, in nephropathic rats was investigated. Methods Renal failure was induced by injection of gentamicin. Acute inflammation was induced by injection of turpentine oil in rats. Serum concentrations of α2M were measured by enzyme-linked immunosorbent assay. Half-life was calculated as 0.693/ elimination rate constant (K). The serum concentrations of α2M were significantly higher during renal failure than in the control. Moreover, the maximum concentrations and total area under the blood concentration vs. time curve were significantly elevated during renal failure. However, the rate of elimination in nephropathic rats was equivalent to that in control rats. Therefore, no significant difference in the α2M half-life was observed between nephropathic and control rats.
- Subjects
MACROGLOBULINS; GENTAMICIN; LABORATORY rats
- Publication
International Journal of Applied Research in Veterinary Medicine, 2017, Vol 15, Issue 2, p126
- ISSN
1559-4602
- Publication type
Article