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- Title
Wound Healing Potential of Transdermal Patches Containing Bioactive Fraction: A Novel Approach.
- Authors
Tripathi, B. D.; Singh, Nitu
- Abstract
Wound healing involves a complex interaction between cells, mediators, growth factors, and cytokines. The cascade of events starts with activation of the procoagulant pathway and recruitment of inflammatory cells and is followed by a phase of cellular proliferation and tissue repair/resolution of the injury. Many biocompatible biomaterials have been extensively investigated to deliver drugs into wound beds and to improve wound healing. Transdermal Drug Delivery System (TDDS) is the most innovative and Novel drug delivery systems by penetrating through the skin by increasing the scope of molecules that can be delivered. TDDS that traditionally uses a patch containing loaded drug substances pressed on to the skin is convenient, painless and non-invasive, to avoid gastro intestinal (GI) tract toxicity (peptic ulcer disease). Chronic wounds and infected wounds currently pose a significant burden worldwide. Drug delivery systems (DDS) in wound healing that release antimicrobial and anti‐inflammatory drugs represent a great opportunity to prevent infections or enhance the effectiveness of current commercial drugs. Several phytoconstituents like alkaloids, flavonoids and tannins are known to promote wound healing process due to their antioxidant and antimicrobial activities. Hence the the transdermal patches containing alkaloid fraction, flavonoid fraction and tannin fraction of plant extracts may shows significant wound healing activity in experimentally induced excision and incision wound model.
- Subjects
TANNINS; TRANSDERMAL medication; WOUND healing; DRUG delivery systems; CHRONIC wounds &; injuries; PEPTIC ulcer; CELL proliferation
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 7, p83
- ISSN
0976-7126
- Publication type
Article