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- Title
EFFECT OF DUAL C-JNK/P38MAPK INHIBITOR MERCURY INDUCED EXPERIMENTAL MODEL OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) IN RATS.
- Authors
Rajeshwar, Yadav; Sidharth, Mehan
- Abstract
Amyotrophic lateral sclerosis (ALS)also known as Motor neurone disease (MND) or Lou Gehrig's disease, is a specific disease that causes the death of neurons controlling voluntary muscles which is characterized by death of upper and lower motor neuron (corticospinal tract) in motor cortex, basal ganglia, brain stem and spinal cord. The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular signal-regulated kinase (ERK), p38, and c-Jun NH(2)-terminal kinase (JNK), with each MAPK signalling pathway consisting of at least three components, a MAPK kinase kinase (MAP3K), a MAPK kinase (MAP2K), and a MAPK. The MAPK pathways are activated by diverse extracellular and intracellular stimuli including peptide growth factors, cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress. These signalling pathways regulate a variety of cellular activities including proliferation, differentiation, survival, and death. Deviation from the strict control of MAPK signalling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers. Hence we can hypothesize that C-JNK/P38MAPK inhibitor can be used to prevention of mercury induced ALS in rats.
- Subjects
MOTOR neuron diseases; AMYOTROPHIC lateral sclerosis; GEHRIG, Lou, 1903-1941; GROWTH factors; MITOGEN-activated protein kinases; ALZHEIMER'S disease; SPINAL cord; MOTOR neurons
- Publication
International Journal of Pharmacy & Life Sciences, 2019, Vol 10, Issue 6, p56
- ISSN
0976-7126
- Publication type
Article