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- Title
Evaluation of Anti-diabetic activity of Poly Herbal Antidiabetic Tablet Glucomap.
- Authors
Shrivastava, Satyaendra K.; Dongre, Nirmal; Dubey, P. K.; Shrivastava, B.; Sharma, Pankaj
- Abstract
Plants used to treat diabetes are of considerable interest as they are recognizing to contain valuable medicinal properties in different parts of the plant species with desire properties. Several species of plant are used in the treatment of diabetes, a disease affecting large number of people worldwide. The present paper deals with antidiabetic activity of polyherbal tablet containing herbs viz., Enicostama littorale Blume. (whole plant), Phyllanthus niruri Linn. (bhooamala), Eugenia jamboloma Linn.(seeds), Eugenia jamboloma Linn.(leaves), Azadirachta indicaA. Juss. (leaves), Terminalia arjuna(bark), Aegle marmelos L. Correa (leaves) and Momordica charantiaLinn. (fruits). The formulation (GT-I) was developed as per standard anti-diabetic tablet glucomap (GT) and anti-diabetic activity was evaluated in alloxan indued model. The data of the blood glucose level of rats treated with Alloxan (150mg/kg body weight) produced diabetes within 72 hours. After 72 hours of Alloxan administered the blood glucose levels of rats were observed. Results indicate effect of administration of feeding the GT-I & GTM on body weight and fluid intake in normal and diabetic rats. Also, effect of administration of feeding the GT-I & GTM on total hemoglobin and urine sugar in normal and diabetic rats were reported. The anti-hyperglycaemic effect of the GT-I & GTM on the fasting blood sugar levels on diabetic rats were recorded. It was revealed in present investigation that the formulated batch GT-I shows significant anti-diabetic activity hen compared to standard drug Glibencamide and standard formulation GT.
- Subjects
HYPOGLYCEMIC agents; PLANT species; MEDICINAL plants; PHYLLANTHUS; ALLOXAN diabetes; THERAPEUTICS
- Publication
International Journal of Pharmacy & Life Sciences, 2017, Vol 8, Issue 11, p46
- ISSN
0976-7126
- Publication type
Article